http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16411221&dopt=Abstract


Pediatr Blood Cancer. 2006 Jan 12; [Epub ahead of print]

Second and third malignant solid tumor in a girl with ovarian Sertoli-Leydig tumor.

Panagiotou JP, Polychronopoulou S, Sofou K, Vanvliet-Constantinidou C, Papandreou E, Haidas S.

Department of Pediatric Hematology/Oncology, "Aghia Sophia" Children's Hospital, Athens, Greece.

We report a Sertoli-Leydig cell (SLC) tumor of the right ovary in a 10-year-old girl, which was dealt with surgical removal. Three months after resection, she presented with a new episode of acute abdomen because of an abdominal mass, which histologically was compatible with an undifferentiated embryonal rhabdomyosarcoma. Chemotherapy, according to SIOP-??? 89 protocol, was administered additionally to radiotherapy (3,960 cGy). Three years after completing treatment, the patient developed a painful swelling at her left upper arm. The diagnosis was Ewing sarcoma of the humerus, which was confirmed by identification of the typical 11; 22 translocation on cytogenetic and molecular analysis of the tumor tissue. The patient died 14 months from Ewing diagnosis due to progressive disease. Pediatr Blood Cancer (c) 2006 Wiley-Liss, Inc.

PMID: 16411221 [PubMed - as supplied by publisher]